Wound-healing activity of Polyphenolic fraction of Strychnos nux vomica Seeds

Abstract

Chemical, physical, microbiological, thermal, or immunological damage to the tissue can result in a wound, which is
defined as the cellular and anatomic disturbance of a tissue. Healing a wound is the process of restoring a damaged
tissue's structure and functionality to something close to its pre-wound state. After an injury, an inflammatory
reaction takes place, and the cells below the dermis (the deepest layer of skin) start to produce more collagen
(connective tissue). The epithelial tissue, or the outer skin, regenerates later. Inflammation, proliferation, and
remodeling are the three phases of wound healing. There is a lot of potential for using plants to treat and mend
wounds. Many plant extracts, which contain beneficial compounds like triterpenes, alkaloids, polyphenols,
flavonoids, tannins, saponins, anthraquinones, and other biomolecules, promote the recovery of wounds. In the
following research, the wound-healing efficacy of Polyphenolic fraction of Strychnos nux vomica was evaluated in
excision and incision wound models. The parameters studied include rate of wound contraction, period of complete
epithelialization, and tensile strength of incision wound. The Polyphenolic fraction of Strychnos nux vomica seed
was found to possess significant wound-healing activity, which was evidenced by decrease in the period of
epithelialization, increase in the rate of wound contraction and skin-breaking strength. The present study has
demonstrated that the Polyphenolic fraction of Strychnos nux vomica seeds have properties that render them capable
of promoting accelerated wound-healing activity compared with placebo control.