General Overview of Anemia in children with chronic kidney disease

Abstract

Background: Some studies also cite the World Health Organization definition of anemia
where children aged 6 months to 6 years are anemic if the hemoglobin count is less than
110 g/L and children aged 6–14 years are considered anemic if it is less than 120 g/L.
The new NKF-KDOQI clinical practice guidelines use NHANES-III reference data to
cite normative values in children.Anemia is a universal problem among children with
chronic kidney disease (CKD). Lower levels of glomerular filtration rate (GFR) are
associated with lower levels of hemoglobin, and in adults the latter is most pronounced
when the GFR falls below 60 mL/min per 1.73 m2 .In children, the relationship between
GFR and anemia is less clear.Most children with CKD will ultimately require treatment
with Recombinant human erythropoietin, which may be administrated intravenously or
subcutaneously, effectively treats anemia both in children with predialysis CKD and
those on maintenance dialysis.