Urinary albumin creatinine ratio (ACR) assessment in hypertensive non diabetics and its association with estimated glomerular filtration rate (eGFR)

Abstract

Microalbuminuria in hypertension has been described as an early sign of kidney damage and 
a predictor for end stage renal disease and cardiovascular disease. Thus, it is of great 
importance to study the association between urinary albumin creatinine ratio and progression 
of kidney disease in hypertensive patients. The presence of microalbuminuria has been shown 
to correlate with the other cardiovascular risk factors commonly seen in hypertensive 
patients. This fact indicates that the detection of an increased urinary albumin excretion could 
probably be the best index of an increased global cardiovascular risk in a hypertensive 
patient. BP control is accompanied by a fall in the content of albumin in urine. Agents with 
the capacity to block the renin-angiotensin system have shown a capacity to decrease urinary 
albumin excretion, which is independent of their ability to lower blood pressure.