Effect of Intracoronary Glycoprotein IIb/IIIa Antagonist and Manual Aspiration on Primary Percutaneous Coronary Intervention Outcome in High Thrombus Burden Patients
DOI:
https://doi.org/10.48047/Keywords:
Intracoronary Glycoprotein, Manual Aspiration Thrombectomy, Percutaneous Coronary Intervention, ST-segment elevation with high thrombus burden.Abstract
Background: The opening of a related artery in myocardial infarction as quickly as possible is the
key to treating infarct. Percutaneous coronary intervention (PCI) for recanalization of related
infarcted arteries is considered the most effective therapy for myocardial infarction. Aim of the
Work: To estimate the intracoronary delivery of glycoprotein IIb/ IIIa following manual thrombus
aspiration on outcomes post PCI for patients with high thrombus burden. Patients and Methods:
The current study was carried out at the cardiology department of Zagazig University that was
conducted on 48 patients presented to zagazig university Hospital's emergence cardiac unit from
March 2021 to November 2021. With ST-elevation myocardial infarction for primary percutaneous
coronary intervention, the need for reperfusion therapy was assessed according to the ESC
Guidelines for the management of acute myocardial infarction in patients presenting with STsegment elevation with high thrombus burden. Results: Combination glycoprotein IIb/IIIa and
manual aspiration is the better then single modality for high thrombus burden patients. Conclusion:
thrombectomy combined with intracoronary GPI treatment could result in improved myocardial
reperfusion, smaller infarcts, better cardiac function, and outcomes in high thrombus burden
patients compared to each treatment alone.
