EVALUATION OF SOME NOVEL 1,3,4-OXADIAZOLE, 1,2,4- TRIAZOLE AND 1,3,5-TRIAZIN

Abstract

In the basic conditions for the production of 1,3,4-oxadiazol-2-thiones (3), aminomethylation by
formaldehyde and secondary amines was carried out with a series of acid-based hydrazides (2) acid
derived from ibuprofen and 4-methylthiophhenylacetes (2) (4 and 5). TLC has confirmed the purity of
the compounds. Based on elementary and spectral analyzes, the structures of these compounds have
been established. The compounds newly synthesized for their anti-inflammatory, analgesic,
ulcerogenic, antimicrobial activity were evaluated.