Relation Between Estimated Creatinine Clearance and Acid-Base Balance Status in CKD Patients- An Observational Cross Sectional Study

Abstract

Aim: Study on Acid-Base Balance Disorders and the Relationship between Its Parameters and
Creatinine Clearance in Patients with CKD.
Methods: A prospective observational study was conducted in the Department of Medicine,
Darbhanga Medical College and Hospital, India, after taking the approval of the protocol
review committee and institutional ethics committee. 220 patients with CKD were included in
this study. CKD Patients who were not undergoing treatment or dialysis and Aged between 18-
70 years were included in this study.
Results: The 220 CRF patients (male: 140, female: 80), aged 18 to 70 years were participated.
The average age of patients was: 47.95±14.03. Patients aged 50-60 accounted for the highest
proportion (20%). CrCl decreased in comparison with normal values and decreased with the
stage of renal failure (P < 0.001). The level of creatinine, urea, uric acid increased with the
stage of renal failure (P <0.05). The mean value of protein and albumin did not change
significantly (P > 0.05). Among CRF patients, metabolic acidosis is predominantly 75%, while
other types of disorders account for a very low rate. This disorder gradually increases with the
stage of renal failure. pH, tCO2, HCO3
- and BE had a moderate positive correlation, only PCO2
have a weak positive correlation with creatinine clearance.
Conclusion: In the study of acid-base balance disorder, we found that different valuable
biochemical indicators in CRF patients were lower than the normal range which gradually
decreased based on the disease severity and stage of renal failure.