A Study to Assess the Prevalence of Hepatobiliary Dysfunction and Ultrasonographic Abnormalities Related to Dengue Fever in Pediatric Age Group

Abstract

Aim: The aim of the present study to evaluate the prevalence of hepatobiliary dysfunction and
ultrasonographic abnormalities in dengue fever in pediatric age group.
Methods: The Prospective, Observational study was conducted in the Department of
pediatrics, Vardhman institute of medical sciences, Pawapuri, Nalanda, Bihar, India, for 18
months. 120 Children below 18 years who were Dengue Non structural antigen protein 1 [NS1]
and/or Immuno- globulin M [IgM] positive only were included in the study. After clinical
assessment, the patients were classified as DF/DHF/DSS. Lab investigations included CBC,
WBC count, platelet count, hematocrit, SGOT, SGPT, PT, APTT and INR was monitored.
Results: In the present study, mean SGOT and SGPT in DSS was statistically significant. Total
serum bilirubin was increased in DSS than in DHF. Total protein, albumin, globulin and ALP
were statistically insignificant. Coagulation profile was increased in all the 3 groups. The mean
SGOT/SGPT in DHF was 107.11±48.36 and 66.78±35.98 and in DSS was 241.25±121.22and
195.12±102.25 with was statistically significant.Total protein, albumin, globulin, and alkaline
phosphatase levels in all the 3 groups were not statistically significant, however bilirubin levels
were higher in DSS when compared to DHF. Ascites, hepatomegaly, pleural effusion and gall
bladder thickening findings in ultrasound were statistically significant in DSS when compared
to DHF. USG showed ascites, pleural effusion, hepatomegaly, gall bladder thickening which
were statistically significant in DSS than in DHF.
Conclusion: The clinical and laboratory markers are helpful for diagnosing and predicting the
course of the disease.