Effect of Abscisic Acid on Diabetic Cardiomyopathy in StreptozotocinNicotinamide-Induced Diabetic Rats
DOI:
https://doi.org/10.48047/Keywords:
(Abscisic acid, diabetic cardiomyopathy, oxidative stress, and anti-diabetic drug).Abstract
The present study was performed to find out the possible protective effect of abscisic acid (ABA) against
diabetic cardiomyopathy (DCM) in type II diabetic rats. Materials and methods: Fifty adult male albino rats
were divided into five equal groups: normal control group, diabetic group, diabetic group treated with
glibenclamide, diabetic group treated with ABA, and diabetic group treated with both glibenclamide and ABA in
combination for 4 weeks. At the end of the experiment, ECG, heart weigh and HW/BW ratio was recorded,
biochemical measurement of diabetic markers (serum glucose, insulin and calculated HOMA-IR); cardiac
enzymes (cardiac troponin I, CK-MB, and LDH);oxidative stress markers in the heart (MDA and catalase) and
histopathological examination of cardiac tissue.Results: Treatment with ABA exerted positive effects on blood
glucose, insulin levels, and insulin resistance that were found to be reflected on heart weight/body weight ratio
and ameliorate the histological morphology of the heart in diabetic rats. Also, it exerted significant improvement
in cardiac enzymes and stress markers. DCM was associated with prolongation of QTc. Conclusion: The
diabetic rats benefit from ABA intake due to its hypoglycemic, anti-inflammatory, antioxidant, anti-fibrotic, and
anti-apoptotic effects or through nitric oxide production improving cardiac perfusion. So, intake of ABA in
combination with anti-diabetic drugs may be beneficial for type II diabetic patients.
