DEVELOPMENT OF AGOMELATIN LOADED NANOSUSPENSION UTILIZING STABILIZER AND SURFACTANT

Abstract

The aim of the present work is to develop oral Nanosuspension of Agomelatin by solvent evaporation method using various
Stabilizers and Surfactants such as PVP K30, Pluronic F127, Urea & SLS. Various formulation as well as process parameters were
optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared Nanosuspension was done with
respect to particle size, zeta potential,
Saturation solubility, dissolution rate, morphology study (SEM), in-vitro dissolution study. Zetapotential value for the best
formulation (F12) was found to -22mv which was found to be within theacceptable limits. Average particle size of nanosuspension of
best formulations(F12) was found to be 118nm. From the invitro studies we can say that formulation F12 shows best drug releaseof
98.65% within 30 minutes where as all the other formulations didn’t release the drug. The drug release from the Nanosuspension was
explained by the using mathematicalmodel equations such as zero order, first order, and equation methods. Based on the
regressionvalues it was concluded that the best formulationF12 follows first order kinetics.