FORMULATION & IN-VITRO EVALUATION OF FLOATING MICRO BALLOONS OF RAMIPRIL

Abstract

Floating drug delivery systems are planned for the less soluble, unbalanced and they have small bulk density than the gastric
content similarly they float in the stomach for an extended period of time. From this the planning of floating microspheres is
one of the method in conveying a dosage form to the target site in sustained controlled release manner, to reach respectable
peak plasma concentration by growing bioavailability of drug or dosage form. In the floating microspheres, the drug
overloaded microspheres arise in contact through gastric fluid the gel formers, poly saccharides and polymer hydrates to
form a colloidal gel barrier then controls the rate of fluid diffusion into the device and consequential drug released by the
inflated polymer depresses the density and float in the stomach. Associating to the conventional dosage form floating
microspheres have enhanced G.I.T absorption, controlled release , site specificity and have probable to increase local action
with extreme gastric retention time and expectable gastric emptying time. The aim of this work was to formulate and
evaluate the floating microballoons containing Ramipril. The floating microballoons were prepared by solvent evaporation
method with the polymer like of hydroxypropyl methyl cellulose and ethyl cellulose. The drug Ramipril was selected is an
ACE inhibitor category and due to its short biological half-life and. poor bioavailability because of poor absorption at lower
GI tract. In this research work my aim is to reduce the dosing frequency and single dose which release the active ingredient
over an extended period of time.