BIO ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TEPOTINIB IN RAT PLASMA WITH LCMS/MS

Authors

  • Ramchandran d, neeharika tirumalasetty Author

DOI:

https://doi.org/10.48047/

Keywords:

tepotinib, lc-ms/ms, usfda guidelines, validation, rat plasma.

Abstract

A highly responsive and simple lc-ms/ms assay was developed and witnessed for the gradation of tepotinib in rat
plasma. The chromatographic conditions involve isocratic mode using waters symmetry c18 (150x4.6 mm, 3.5 µ)
column. A mobile phase of 0.1% opa (ortho phosphoric acid) and acetonitrile in 50:50 is used and the detection was
carried out in a +ve mode of electro spray ionization by using ms and entrectinib was used as internal standard. The
lc-ms/ms method and validated in accordance with usfda guidelines.

Downloads

Download data is not yet available.

Downloads

Published

2021-04-21

Issue

Vol. 12 No. 4 (2021): volume 12 issue 4 (2021)

Section

Articles