FORMULATION AND EVALUATION OF TOLTERODINE EXTENDED RELEASE TABLETS

Abstract

The present work was aimed with the objective of “’’ to reduce the overactive bladder
problem in elderly patients. The tablets were prepared by using different polymers like HPMC k4M, HPMC
K100M, Xanthan gum etc. Particular attention was given to concentration of different polymers. The
concentrations of both polymers HPMC K4M and HPMC K100M shown big obstacle to release the drug for
24hrs with similar to innovator Detrol La tablets. The tablets were evaluated in terms of Tolterodine content,
mechanical properties, dissolution test, FT-IR studies revealed that there is no interaction between the drug
and the polymers used in the study. The promising tablet F11 having the optimal formula showing the greatest
dissolution properties when compared to other formulations.