Molecular Detection of gene Leptin receptor promoter (Lepr) in female rats treated with Drug

Abstract

The aim of the research is the molecular detection that metformin and propylthiouracil induce on 
the leptin gene .The research was conducted on female rats with an average weight ranging from
150-180 grams and an age group ranging from 4.5-5.5 months, was divided into four groups and 
all groups were given water and food throughout the trial period, the results of the current study 
showed that metformin and propyl thiouracil in terms of mutation rate, as the combination
therapy resulted in higher values in the percentage of mutations and deletions