ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF GLIPIZIDE BY LIQUISOLID TECHNIQUE

Abstract

Liqui-solid technique are novel approach for enhancement of dissolution rate of BCS class II drugs. Liqui-solid
compact converts a liquid drug or drug solution into a free flowing powder with enhanced dissolution rate. In the
present study, Liqui-solid compacts is applied to enhance the dissolution of the Glipizide Twenty two formulations
of Glipizide were prepared by liqui-solid technique using micro crystalline cellulose as carrier material and Aerosil
and Crosspovidone ascoating material. Water, poly ethylene glycol-600 and Tween-80 were used as solvent system .
Tablets were subjected to evaluation of various physical and chemical characteristics. Dissolution profiles of tablets
prepared by the novel techniques were compared with marketed conventional tablets. Model independent techniques
including similarity factor, dissimilarity factor and dissolution efficiency were applied for comparison of dissolution
profiles. The results obtained indicated that liqui-solid compact formulations were more effective in enhancing the
dissolution rate. The liqui-solid compacts improved the dissolution rate