SOLID STATE INVESTIGATION OF NABUMETONE
DOI:
https://doi.org/10.48047/Keywords:
Nabumetone, Glipizide, Solubility, Ethanol, Dissolution, Crystals.Abstract
The present report was aimed at solid state manipulation of nabumetone. Nabumetone is a nonsteroidal
anti inflammatory agent with slightly low risk of GI side effects. Different crystal forms of nabumetone
were prepared using solvents of different polarity by four techniques, namely solvent evaporation,
heating, quench-cooling and seeding. Microscopy, FTIR, X-ray diffractometry (XRD), and differential
scanning calorimetry (DSC), were used to characterize crystalline forms of the nabumetone. Acicular and
rod shaped crystals were obtained. Metastable polymorphs of nabumetone were identified on the basis of
low melting points, and converted into stable form as indicated by the high melting point over a period of 2
months. The polymorph was identified as Form II was reported by earlier works. Evidence indicated that
there are two different crystal habit of nabumetone. Physicochemical properties such as melting point,
solubility and dissolution were evaluated. Crystals obtained from isopropyl alcohol, and isobutyl alcohol
had nearly two fold higher aqueous solubility. Crystals obtained from ethanol has gradual and increased
dissolution rate. These crystals may have still low risk of GI side effects.
