FORMULATION,DEVELOPMENTAND EVALUATION OF FLOATING ORAL IN-SITU GEL CONTAINING IVABRADINE

Abstract

Liquid Oral conventional dosage forms shows low bioavalability due to their rapid gastric transit time from the
stomach. In this study novel approach used in the form of gastroretentive floating in - situ gel system have been
developed to delivered drugs in a controlled manner. Liquid orals are low bioavailability because they are
eliminated rapidly from the stomach. This problem overcome by development of oral insitu gels. Ivabradine oral
in-situ gelling systems were prepared by using polymers like Guar gum, Xanthan gum, HPMC K15M, and
Carbopol 940, Sodium citrate, Calcium carbonate and Sodium alginate. Total of twelve (F1 to F12)
formulations were prepared and F12 was found to be the best formulation Carbopol 940. Drug and polymers
was subjected for compatibility study using FTIR studies, which revealed that there was no interaction between
drug and polymers. The prepared formulations were evaluated for drug content, floating lag time, total floating
time, viscosity, gelling nature, visual appearance &invitro release studies were also performed. The
invitrorelease studies of all the formulations among them F12 formulation containing carbopol 940 shows drug
release of 98.42% by the end of 12hrs. The release kinetics of the optimized formulation was best fitted into
Higuchi model (R2 =0.991) and showed zero order (R2 =0.994) drug release with super case transport
mechanism.