NEUROPHARMACOLOGICAL SCREENING OF FLAVONOIDS AGAINST MK-801 INDUCED STEREOTYPY AND ANTI ANXIETY ACTIVITY

Abstract

Objective:The effects of Quercetin and Naringin were investigated on stereotypyes induced by the N-methyl-DAspartate (NMDA)-type glutamate receptors agonist MK-801 (Diazocilpine maleate) and Diazepam induced
anxiety in SD rats.
Methods: Glutamate/NMDA receptors are located throughout the brain; Glutamatergic models predict
widespread cortical dysfunction with particular involvement of NMDA receptors throughout the brain. Further,
NMDA receptors are located on brain circuits that regulate dopamine release, suggesting that dopaminergic
deficits in schizophrenia may also be secondary to underlying glutamatergic dysfunction.NMDA receptors are
widely distributed throughout cortex. MK801- induced stereotypic behaviour was also measured. Results and
conclusion:The selective flavonoids Quercetin and Naringin exhibited significant antipsychotic activity in a
dose dependent manner comparable to the standard drugs, Haloperidol (0.5mg/kg, i.p.) and Diazepam(10 mg/kg,
i.p.) at the dose of 100, 50 and 25 mg/kg for Quercetin; 80; 40 and 20mg/kg for Naringin respectively.