DEVELOPMENT AND EVALUATION OF EUDRAGIT FLOATING MICROSPHERES CONTAINING EZETIMIBE

Abstract

The purpose of this research work was to formulate and evaluate the floating microspheres of poorly water-soluble
drug, ezetimibe by emulsion solvent diffusion evaporation technique using eudragit RS 100 and eudragit RL 100.
The formulated microspheres were characterized for various parameters. The microspheres with Eudragit RS 100
showed drug loading of 20.9 to 81.8% and the particle size of 2.631 to 7.254 µmand the microspheres with Eudragit
RL 100 showed drug loading of 63.5 to 73.6%, the particle size distribution of 1.549 to 5.962 µm. The prepared
microspheres were white, free-flowing and virtually spherical in shape.The drug release was extended up to 10 h and
its release mechanism from formulations followed the super case-II transport which indicated that drug release from
floating microspheres by diffusion controlled polymeric relaxation.