THE DEVELOPMENT AND EVALUTIONOF NANOSPONGES DRUG DELIVERY SYSTEM OF KETOPROFIN BY USING SOLVENT EVAPORATION METHOD.
DOI:
https://doi.org/10.48047/Keywords:
Ketoprofen, Ethyl cellulose, Poloxamer, β-cyclodextrin, FTIR.Abstract
The Aim ofthisworkistothedevelopmentandevaluationofNanosponges drug delivery system of Ketoprofen
by using solvent evaporation method.Ketoprofen is a BCS classII drug, having anhalf life of 1.1-4 hours,
which wasn’t suitable for maintaining constant plasma concentrations. So Ketoprofen was formulated as a
Nanosponge formulation for effective drug release. KetoprofenNanosponges was formulated using poloxamer,
ethyl cellulose, β-cyclodextrin with four different drug: polymer rations. FTIR spectroscopy analyses indicated
the chemically stable, amorphous nature of the drug in these Nanosponge. SEM photographs revealed the
spherical nature of the Nanosponge in all variations. The formulation F8 has better results than remaining
formulations. F8 formulation shows better entrapment efficiency than other formulations, drug release
release96.42 % in 12 hour, and follows zero order with supercase II transport mechanism.
