Efficacy of thrombolytic therapy with IV streptokinase in acute ST elevation myocardial infarction patients at tertiary care hospital in Gujarat

Abstract

Aim: The aim of this study was to assess the efficacy of thrombolytic therapy with IV streptokinase in
acute ST elevation myocardial infarction patients.
Methods: An observational study was conducted in the Department of Medicine, Baroda Medical
College and S.S.G. Hospital, Vadodara, Gujarat. Total 90 Patients with diagnosis of acute ST segment
elevation before and after thrombolysis with Streptokinase were included in this study. Based on values
obtained, study population divided into three categories. Category A: <30% resolution of the sum of ST
segment elevation. Category B: 30%-70% resolution of the sum of ST segment elevation. Category C:
>70% resolution of the sum of ST segment elevation.
Results: Mean age of present study is 54.8±10.5 years. Male patients were significantly increased
(77.78%) when compared with Female patients (22.22%). The chest pain was the most common mode of
presentation. Complete ST resolution seen among 40% cases, partial resolution seen among 45.55% and
no resolution among 14.44% cases. Thrombolysis time of <3 hours, 3-5 hours and more than 5 hours was
noted in A, B and C categories patients.
Conclusion: For thrombolysis in acute STEMI, IV streptokinase is 40 percent effective, according to
research. Adverse events were more common in patients who did not have an improvement in their ST
segment 90 minutes after thrombolysis was administered to them