ANTI-DIABETIC EFFECT OF CANNABIGEROLIC ACID (CBGA) IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Abstract

Aim: To investigate the anti-diabetic effects of cannabigerolic acid in streptozotocin-(STZ) induced diabetic
rats.
Materials and methods: The five groups in this study were, Group I -Normal control, Group II-Diabetic control,
Group III-Glibenclamide 5 mg/kg p.o., Group IV- cannabigerolic acid 50 mg/kg/p.o. and Group Vcannabigerolic acid 100 mg/kg/ p.o., respectively. The anti-diabetic activity was assessed using blood glucose
level and various biochemical parameters like serum total cholesterol level (TC), triglyceride (TG) level, highdensity lipoproteins (HDL), total protein (TP), alanine aminotransferase (ALT), aspartate aminotransferase
(AST) and Insulin, respectively. The biochemical indicator assessment was done from the each group with 10%
w/v homogenate liver for determination of lipid peroxidation-malondialdehyde (MDA), reduce glutathione
(GSH) level, superoxide dismutase (SOD) and catalase activity (CAT).
Results: Cannabigerolic acid exhibited an antidiabetic effect by significantly decreased the level of blood
glucose, TC, TG, TP and increase HDL as well as serum insulin level. The results of the study demonstrated that
the treatment with cannabigerolic acid was significantly (P<0.05) and dose-dependently prevented STZ -induced
diabetic rats. CBGA were significantly (p < 0.001) increased SOD, CAT and GSH level and decrease found in
lipid peroxidation (p>0.05).
Conclusions: The findings of the study suggest that cannabigerolic acid possess potential antidiabetic activity as
it lowers serum glucose level.