ANTIULCER EFFECTS OF AGOMELATINE AND ITS POTENTIATION WITH PYRIDOXINE

Abstract

Agomelatine is a manufactured simple of melatonin and a strong agonist of melatonin
receptors. Agomelatine has Hepatoprotective just as cancer prevention agent action. The
point of study was to assess the antiulcer action of Agomelatine and its potentiation
through the pyridoxine on ethanol initiated gastric ulcer in rodents.
Methods: Thirty number of rodents were separated in to five gatherings contro,
standard, Agomelatine low portion, Agomelatine high portion and Agomelatine with
Pyridoxine gatherings. Ethanol was utilized to prompted gastric ulcer in rodents. ulcer
record and furthermore the other biochemical boundaries like free Acidity, complete
Acidity, gastric pH, volume of gastric juice was resolved. Measurably examination was
finished by ANOVA P esteem under 0.05 was viewed as statistically significant.
Results: In the current investigation, an endeavor has been made to research the gastric
antisecretory, antiulcer and cytoprotective properties of agomelatine. The outcomes are
genuinely huge by ANOVA test. Ranitidine showed a measurably critical reduction in
the volume of gastric juice by free corrosiveness and complete sharpness. when
contrasted with control. Agomelatine shows a showed comparable reaction to the
volume of gastric juice. A huge distinction in pH was seen between the agomelatinetreated, agomelatine with pyridoxine treated gathering and the control
groups.Conclusions: Pretreated rodents with Agomelatine (40 milligram/kg) showed
defensive impact against ethanol actuategastric ulcer. Agomelatine (40 milligram/kg)
showed the ameliorative impact with Pyridoxine (0.3 milligram/kg), on gastric ulcer.