EFFECT OF GREVILLEA ROBUSTA LEAF ON ANTIDIABETIC ACTIVITY

Abstract

Hypercholesterolemia and the resulting have been implicated the path physiology of coronary
heart diseases and myocardial ischemia. Lowering cholesterol level may decrease the risk of
CVD, and therefore enormous efforts have been extended achieve this aim. The
hypocholesterolaemia activity of ethanol extract of Grevillea Robusta (GRLE) against
hypercholesterolemia was monitored on the Lipid profile status, antioxidant status, activities of
serum cardiac marker enzyme, and histological changes of liver and heart. In this study the high
cholesterol diet (HCD) is used which consists of maize, soya meal, coconut cake, rice polish,
groundnut cake and animal tallow which has been used in inducing experimental
hypercholesterolemia In the current study, the HCD fed rats showed increased levels of plasma
cholesterol (TC), and triglycerides (TG) levels compared to normal control rats. Treatment with
GRLE significantly decreased the levels of serum TC, when compared to HCD induced rats.
Saponins are also reported to precipitate cholesterol from micelles and interfere with enter
hepatic circulation of bile acids making it unavailable for intestinal absorption, this forces liver
to produce more bile from cholesterol and hence the reduction in serum cholesterol level.
Saponins are also reported to lower triglycerides by inhibiting pancreatic lipoprotein lipase.
Similarly in our study also, the presence of both flavonoids and saponins in could have
contributed in reducing the levels of lipid status (TC, TG,) elevated levels of serum low density
lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) are often
accompanied by premature atherosclerosis and other CVD. FEA low level of high-density
lipoprotein cholesterol (HDL) is also an important risk factor for cardiovascular disease.