Factors Influencing Online Prediction Tools of NonAlcoholic Fatty Liver Disease

Abstract

Objective: This studyaimed to identify clinical parameters which are highly influencing with Fatty Liver Index (FLI), lipid accumulation product (LAP), hepatic steatosis index (HSI),NAFLD liver fat score (NAFLDLFS),Triglyceride and Glucose index(TYG). Materials and Methods: This was a prospective observational study conducted in 128 patients aged between >18-80 years who attended SRM medical hospital and research center during July -Dec 2020. Based on inclusion and exclusion criteria, inultrasound diagnosed NAFLD patients the lab values are collected. These collected lab values are correlated with FLI, LAP, HSI, NAFLD-LFS, TYG according to cut-off values. Results:This analysis shown a strong negative correlation found between FLI <30, FPG (P=0.044). Moderate positive correlations were found between FLI 30-<60 and BMI (P=0.010), WC (P=0.003). In the case of FLI >60, there is a moderate positive correlation found between FLI and weight (P<0.0001), BMI (<0.0001), WC (<0.0001), and weak positive correlation with TG (P=0.007), GGT (P=0.033). LAP<80 shown a strong positive correlation with TG (P<0.0001), a weak positive correlation with HOMA-IR (P= 0.045), and a weak negative correlation with Ht (P=0.011). LAP >80 shown a strong positive correlation with TG (P<0.0001). HSI <36 shown a moderate positive correlation in BMI (P=0.028). HSI >36 shown a moderate positive correlation in Wt (P<0.0001), WC (P<0.0001), fasting insulin (P=0.002), and a strong positive correlation with BMI (P<0.0001). NAFLD-LFS <-0.640 shown a weak positive correlation in fasting insulin (P=0.0407). NAFLD-LFS >-0.640 shown a strong positive correlation in AST (P<0.0001), moderate positive correlation with ALT (P<0.0001), fasting insulin (P<0.0001), and weak positive correlation with HOMA-IR (P=0.001). TYG >4.49 shown strong positive correlations in FPG (<0.0001), TG (P<0.0001), weak positive correlation with HOMA-IR (P=0.049).TYG >4.49 shown a weak negative correlation with BMI (P=0.007). Conclusion:Other than variables derived to calculateFatty Liver Index (FLI), lipid accumulation product (LAP), hepatic steatosis index (HSI),NAFLD liver fat score (NAFLD-LFS),Triglyceride and Glucose index(TYG);FPG, insulin resistance, fasting insulin found to have a significant correlation.