EFFECT OF ISOPROTERENOL AND THYROXINE IN HERBAL DRUG USED AS CARDIAC HYPERTROPHY

Abstract

OBJECTIVE
 The impact of A. calamus extract and C. Pereira extract on heart hypertrophy caused by isoproterenol. A. calamus
extract & C. Pereira extract on heart hypertrophy by thyroxine.
MATERIAL AND METHOD
a. Animal House Pharmacy School (Wistar rats), measuring 180-250 grammes, BIT Meerut (UP). One week
before the research began, they were kept separately in polypropylene cages in a quarantine room.
b. C. Pareira and A. calamus rhizomes from the School of Pharmacy at the Medicinal Garden, BIT, Merrut,
UP, India.
METHODS
 Influence of C. Pareria Extract on Isoproterenol- induced cardiac hypertrophy in rats.
 Influence of A. Calamus Extract on Isoproterenol- induced cardiac hypertrophy in rats. Influence of C.
Pareria Extract on Thyroxine- induced cardiac hypertrophy in rats
 Influence of A Calamus Extract on Thyroxine- induced cardiac hypertrophy in rats.
RESULTS
In comparison with control and C. Pareira and A. Calamus as well as amlodipine treated groups in the ISO treatment
community, no major alteration was identified in the MAP. There was no MAP change in T4 compared with
controls and groups C. pareira and amlodipine treated with T4. Significantly increased T4 (P < O.O1) HR
administration against power.No significant change in HR was detected in C. Pareira and A. calamus.
CONCULSION
Cissampelos pareira and Acorn calamus effect in cardiac hypertrophy induced by isoproterenol
Isoproterenol chronic administration (5 mg/lcg/day, 30 days), cardiac hypertrophy, cardiac weight ratio, angiotensin
II, tumour factor necrosis, calcineurin, oxide/reactive nitrients, NaV K'^-ATPase, antioxidant and NaVK'^-ATPase,
active component antioxidants Both of these changes in the therapy of Cissampelos pareira (100 and 200 mg/kg/day,
30 days) and Acorus calamus (100 and 200 mg/kg/day, 30 days) were substantially enhanced.
 Effect of thyroxin-induced cardiac hypertrophy on Cissampelos pareira and Acorus calamus
The continuous thyroxine (0.1 mg/kg/day, for 30 days) was characterised by hypertropy of the heart and heart and
body weight ratios, Angiotensin II, tumour necrosis factor, calcineurine, nitric oxide and thyrobarbituric acid, and a
substantial decrease. Hypertrophy of the heart Cissampelos pareira (100 and 200 mg/kg/day) and Acorus calamus
(100 and 200 mG/kg/day) have been decreased to almost normal in the next 30 days.