INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE

Abstract

The present pharmacological research work was accomplished to explore the analgesic and antipyretic potential
of Niclosamide (50 and 100 mg/kg, p.o.).Acetic acid induced writhing and Eddy’s hot-plate model was used to
evaluate analgesic effect while antipyretic effect was assessed against brewer`s yeast induced pyrexia in rat. In
writhing activity is significantly decreases 27.06% and 49.74% in acetic acid induced analgesia model while
latency period of Eddy’s hot-plate model is significantly increases 12.17±0.310 and 14.34±0.349 at low and
high dose of Niclosamide (50 and 100 mg/kg, p.o.). It also effectively suppress anal temperature at both high
and low doses significantly 96.43±0.009 and 96.42±0.003 respectively in Brewer’s yeast induced pyrexia.
Preliminary experimental outcome is clearly indicates that Niclosamide (50 and 100 mg/kg,p.o.) is having
significant analgesic and antipyretic potential.