EFFECT OF VARYING DOSES OF ACE INHIBITOR DRUG LISINOPRIL ON DEVELOPMENTAL STAGES OF CHICK EMBRYO

Abstract

Hypertension is common and significant issue experienced by the majority of women during pregnancy.
However treating hypertension during pregnancy is very challenging due to the complications caused by the
antihypertensive drugs which pose risk on the health of both fetus and mother. Few researches have been carried
out to investigate the effects of antihypertensive drugs on the fetus. Controlled studies on Lisinopril drug are not
available. Our study aimed to investigate the effect of lisinopril using chick embryo as a model organism. A
total of 32 disease free Sussex chicken eggs were selected and categorized into four groups containing one
control and three experimental. After 24 hours the eggs were opened by windowing and injected with lisinopril
drug of varying doses, and then closed again using sticky tape. On 15th day the eggs were opened and assessed
for their morphological development and their also they were accessed for their hatching time. Treatment with
lisinopril significantly affected the features and down neural tube development. The intermediate doses showed
more significant results than the highest group when compared to control lisinopril had a negative effect on
chick development. Further research is needed for identification of safe and effective drug in order to treat high
blood pressure during the pregnancy.