OXIDATIVE ECLIPSE: PROTEIN REDOX IMBALANCE IN DIABETIC CATARACT – AN INVITRO STUDY ON GOAT LENSES

Abstract

Background: Long-lived proteins (LLPs) are essential for cellular architecture, especially in 
tissues like the eye lens. However, due to their extended lifespan, they are susceptible to posttranslational modifications like oxidative damage and glycation. Maintaining the redox status 
within cells is crucial for LLP functionality. Cataracts, caused by the clouding of the eye's 
natural lens, are a primary cause of visual impairment and blindness. Chronic hyperglycemia 
in diabetes increases the risk of cataract formation due to metabolic disturbances.