A PROSPECTIVE COMPARATIVE TWO ARM STUDY OF THE ROLE OF ORAL PROBIOTICS IN THE SURGICAL WOUND HEALING – A STUDY OF 100 CASES
DOI:
https://doi.org/10.48047/Keywords:
Surgical wound healing, Oral probiotics, De Simone Formulation, Southampton ScoreAbstract
Background: The process of wound healing is well coordinated and involves a complex interplay
of cellular and molecular events. Any interruptions in this process of wound healing may result
into complications like delayed wound healing, higher infection rate and impaired tissue
regeneration. This further leads to longer hospital stay, dampened quality of life, and higher
healthcare expenses.
Skin microbiome provides protection from external threats and keeps a robust homeostasis.
Surgical procedures disrupts the skin continuity which marks the beginning of process of wound
healing. The phases of wound healing are hemostasis, inflammation, proliferation, and
remodeling. Severe wound site infections by endogenous flora and antibiotics resistant
pathogens, hinders the process of wound healing. Globally reported rates of surgical site
infection varies from 2.5% to 41.9%. Escherichia coli, Staphylococci, and Enterococci are the
predominant pathogens identified as causes in postoperative wounds.[
