Family history of type 2 diabetes and prevalence of metabolic syndrome in adult Asian Indians

Abstract

Background:2XUREMHFWLYHZDVWRWHVWWKHDVVRFLDWLRQEHWZHHQIDPLOLDOULVNRIW\SHGLDEHWHVPHOOLWXV 7'0 
and the prevalence of metabolic syndrome (MS) in adult Asian Indians. Materials and Methods: A total of DGXOW !\HDUV LQGLYLGXDOV PDOHVDQGIHPDOHV SDUWLFLSDWHGLQWKHVWXG\)DPLOLDOULVNRI7'0
ZDVFODVVL¿HGLQWRWKUHHJURXSVYL] ERWKSDUHQWVDIIHFWHG SDUHQWDQGRUVLEOLQJVDIIHFWHGDQG QRQHRU
no family history for T2DM. Anthropometric measures, blood pressures, fasting blood glucose and metabolic SUR¿OHVZHUHVWXGLHGXVLQJVWDQGDUGWHFKQLTXHV06ZDVGH¿QHGDFFRUGLQJO\7KHSUHYDOHQFHRI06SKHQRW\SHV
was estimated and compared among the three familial risk strata. Results: Individuals with a history of both
SDUHQWVDIIHFWHGIURPGLDEHWHVKDGVLJQL¿FDQWO\KLJKHU P<0.001) body mass index (BMI), waist circumference
 :& ZDLVWKLSUDWLR :+5 V\VWROLFEORRGSUHVVXUH 6%3 GLDVWROLFEORRGSUHVVXUH '%3 DQGIDVWLQJEORRG
JOXFRVH )%*P= WKDQLQGLYLGXDOVKDYLQJQRIDPLO\KLVWRU\RI7'06LJQL¿FDQWGLIIHUHQFHZDVDOVR
noticed between individuals with and without MS according to the family history of diabetes (P<0.001).
'LIIHUHQFHVZHUHHYLGHQWEHWZHHQLQGLYLGXDOVZKRIXO¿OOHGDOOWKH06FULWHULD P=0.001) and individuals with
only one or two criteria (phenotypes) according to family history of T2DM. Conclusion: Family history of 7'0KDGVLJQL¿FDQWHIIHFWRQLQGLYLGXDOVZLWK06DVFRPSDUHGWRWKHLUFRXQWHUSDUWV LQGLYLGXDOVKDYLQJQR
family history of T2DM). It therefore seems reasonable to argue that family history of T2DM could be useful as a predictive tool for early diagnosis and prevention of MS in Asian Indian population.