A study to compare the influence of buprenorphine and clonidine when either drug was injected intrathecally as an adjuvant to bupivacaine in infra umbilical surgeries

Abstract

Intrathecal Clonidine is being extensively evaluated as an alternative to neuraxial opioids for control of
pain and has proven to be a potent analgesic, free of at least some of the opioids related side effects.
It was not unexpected that Clonidine, an alpha 2 adrenergic agonist, had beneficial effect of improved
quality of intraoperative analgesia, and in last two decades several studies have demonstrated that
Clonidine administered spinally or epidurally has potent antinociceptive action through an alpha
adrenergic mediated mechanism in the dorsal horn of the spinal cord. This action exists for both somatic
and visceral pain.