Effect of oral Clonidine premedication before anaesthesia: Double blindprospective randomized study.

Abstract

Background: Haemodynamic fluctuations, higher myocardial oxygen demand and cardiac arrhythmia are undesirable but inevitable side effects of laryngoscopy and endotracheal intubate on. This is a concern in all patients especially in patients with coronary artery disease, valvular heart disease, elevated intracranial pressure and cerebrovascular disease.The induction of anesthesia, laryngoscopy, tracheal intubation and surgical stimulation often evoke cardiovascular responses characterized by alteration in systemic arterial blood pressure, heart rate and cardiac rhythm. The response following laryngoscopy and intubation often peaks at 1.2 minutes and return to baseline within 5 to 10 minutes.