DETERMINANTS OF RENAL OXYGEN METABOLISM DURING LOW NA+ DIET: EFFECT OF ANGIOTENSIN II AT1 AND ALDOSTERONE RECEPTOR BLOCKADE

Abstract

Background: Renal oxygen metabolism plays a crucial role in kidney function, especially under conditions of sodium restriction. This study evaluated the effects of angiotensin II AT1 receptor and aldosterone receptor blockade on renal oxygenation in the context of a low Na+ diet. Methods: A randomized, controlled, crossover trial was conducted at JLNMCH Bhagalpur, involving 60 participants divided into two groups: AT1 receptor blockade and aldosterone receptor blockade. Participants underwent BOLD-MRI to assess renal oxygenation pre- and post-treatment, and renal function tests measured changes in sodium excretion and renal blood flow.