COMPARATIVE ANALYSIS OF IMMUNOHISTOCHEMICAL AND MOLECULAR BIOMARKERS IN BREAST CANCER AND THEIR CORRELATION WITH CLINICAL OUTCOMES: A RETROSPECTIVE STUDY

Abstract

Background: Breast cancer heterogeneity necessitates the use of biomarkers for personalized treatment strategies. This retrospective study explores the association between immunohistochemical and molecular biomarkers in breast cancer and their impact on clinical outcomes. Methods: Data from 100 breast cancer patients treated at a single institution were analyzed retrospectively. The study focused on the expression levels of key immunohistochemical markers (ER+, PR+, HER2+, Ki-67, and Triple Negative) and molecular profiles (specific genetic mutations and epigenetic alterations). Statistical analyses were conducted to examine the correlation between these biomarkers and patient outcomes, including treatment response and survival rates.