FORMULATION AND EVALUATION OF RISEDRONATE SODIUM NANOSPONGES
DOI:
https://doi.org/10.48047/Keywords:
quasi-emulsion solvent diffusion, 32 complete factorial design, in vitro buoyancy, in vitro drug release, risedronate sodium nanosponges.Abstract
The goal of the current study was to provide a unique approach to improve risedronate sodium's bioavailability, since it absorbs poorly and inconsistently. Using the modified quasiemulsion solvent diffusion technique, nanosponges were statistically developed through a full 32 factorial design with Design of Experiment software, taking into account the concentration of the polymer and stabilizer as independent variables and the particle size and entrapment efficiency as experimental responses. The optimized formulation had a zeta potential of -35.4 mV, a particle size of 155.8±2.17 nm, and an entrapment efficiency of 67.27±1.05%. According to the Higuchi model's diffusion-controlled release mechanism, the in
vitro release study's findings demonstrated burst release during the first two hours, followed by gradual and sustained release over the next 24 hours
