Superoxide solution (OXUM) vs povidone-iodine dressing in the management of diabetic foot ulcers: A prospective study

Abstract

Aim: Diabetic foot ulcers (DFUs) are prevalent complication in diabetes, leading to significant morbidity and risk of lower limb amputation. Super-oxidized solutions (SOS) are emerging as a promising alternative to traditional antiseptics like povidone iodine due to their antimicrobial properties and reduced cytotoxicity. This study aimed to compare the effectiveness of super-oxidized solution dressings with povidone iodine dressings in the management of infected diabetic ulcers. Materials and Methods: A prospective, randomized, non-blinded study conducted in a tertiary care center on 120 patients with diabetic ulcers, divided into two groups of 60 each. Group A received topical super-oxidized solution dressings, while Group B received topical povidone iodine dressings. Ulcer size, granulation, tissue quality, and discharge were assessed weekly for two weeks. Results: The study included 73.33% males and 26.67% females, with mean ages of 54.90 ± 13.67 years in Group A and 50.50 ± 12.78 years in Group B. Type 2 diabetes prevalence was 93.33% in Group A and 90.00% in Group B. Initial ulcer areas were comparable. Group A demonstrated a significantly greater reduction in ulcer area (1587 ± 832 mm² vs. 2381 ± 1200 mm²; p=0.008) and higher percentage of ulcer reduction (59.90 ± 5.11% vs. 41.90 ± 8.66%; p=0.021). Pseudomonas aeruginosa and Staphylococcus aureus were the most common organisms isolated in Groups A and B, respectively. Conclusion: Super-oxidized solution dressings significantly improved healing outcomes in infected diabetic ulcers compared to povidone iodine dressings, making them a viable alternative for Diabetic Foot Ulcer management.