The Effects of Percutaneous Mitral Balloon Valvuloplasty on the Left Atrial Appendage Function in Patients With Sinus Rhythm and Atrial Fibrillation : An observational study

Abstract

• BACKGR0UND: LAA has an important pathophysiological function because it is more
compliance than the LA and its contractile capacity prevents blood stasis.1,2 LAA velocity
is an important parameter that worsens in mitral stenosis. LAA velocity is an important
predictor of thrombus formation, independent of other hemostatic variables, including
platelet and thrombotic activity. The Effects of Percutaneous Mitral Balloon
Valvuloplasty on the Left Atrial Appendage Function in Patients With Severe MS is
studied in this article.
• Results : Of 50 patients 33 were in NSR and 17 were in AF. Female constituted 78 %
and male 22% of study population. 72% of males were in AF whereas only 23% females
were in AF with p value of 0.002. LVEF, LVEDD (P = 0.050) and LVESD (P =0.068)
did not change significantly after PTMC. MVMG (P<0.001), MVEDG (P<0.001), and
PASP (P<0.001) decreased significantly after PTMC with significant increase in MVA
(P<0.001). LAA emptying velocity (LAAEV) and LAA filling velocity(LAAFV) were
increased significantly (P<0.001).
• Conclusion: This study showed that PTMC is able to improve the clinical status, reduce
SEC, and improve LAA function in patients with MS in both SR and AF rhythms.
Therefore, PTMC may decrease the risk of thrombo-embolism by improving LA and
LAA performance.