Comparative Evaluation of Different Thrombolytic Agents in CAD Patients: Insights from a Single-Time point Angiographic Analysis

Abstract

Background: Coronary artery disease (CAD) remains a chief contributor to global morbidity and mortality. Thrombolytic therapy offers a crucial avenue for the management of CAD, particularly during acute presentations. Although multiple thrombolytic agents are available, comprehensive comparisons of their efficacy in CAD settings, particularly using angiographic measures, are relatively scarce. Objective: This study aimed to conduct a comparative evaluation of several thrombolytic agents in CAD patients, drawing insights from a single-timepoint angiographic analysis. Methods: A retrospective cohort study was designed involving 200 CAD patients. Patients were grouped based on the thrombolytic agent administered. The primary metric was the degree of reperfusion achieved, as captured angiographically post-administration. Secondary outcomes included procedural complications and short-term clinical sequelae. Results: Initial angiographic analysis denoted distinct variations in reperfusion rates across the thrombolytic agents. Some agents showed a notably higher degree of reperfusion while others manifested marginally lower efficacy. Additionally, specific agents were correlated with a higher prevalence of procedural complications. Comprehensive results and statistical nuances will be detailed in the main content. Conclusion: This research provides pivotal insights into the comparative performance of different thrombolytic agents in CAD patients, facilitating an evidence-based approach for clinical decision-making. Future multi-centre, prospective studies with extended follow-ups could further enrich these findings.