ASSESSMENT OF VITAMIN D LEVEL IN HEART FAILURE PATIENTS – A CROSS SECTIONAL STUDY

Abstract

Background: Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavourable outcomes. Objectives: The present study investigated the prevalence of vitamin D deficiency and its relationship with cardio metabolic parameters in heart failure (HF) patients Methods: This was a cross-sectional study, enrolled ≥40 years age group HF patients. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when level <20 ng/ml. Socio-demographic data, history, physical examination and relevant investigation was done in all recruited patients. Results: Patients with HF had a higher prevalence (29.2%) of Vitamin d deficiency. Majority of the patients (35.8%) were 51-60 years age group with mean age was 55.63 years, slightly female predominance. Vitamin d deficiency were significantly associated with female sex and diabetes mellitus (p=0.01). There were no differences between the groups with and without Vitamin d deficiency regarding NYHA-FC, classification of LVEF, body mass index, history of smoking and alcohol ingestion (p>0.05). eGFR was significantly lower whereas PTH was significantly higher in vitamin d deficiency patients (p<0.05). Conclusion: Vitamin D deficiency (25(OH) D and 1, 25(OH) 2D) was significantly associated with heart failure in cross-sectional analyses and predict future deaths due to heart failure. Keywords: Vitamin d deficiency, heart failure, vitamin d, 25 hydroxyvitamin d, 1, 25(OH) D