The safety of 0.1% adapalene with 1% Clindamycin vs 0.1% Adapalene with 2.5% Benzoyl Peroxide in treating mild to moderate acne vulgaris in northern India.

Abstract

To determine the safety of 0.1% adapalene with 1% Clindamycin vs 0.1% Adapalene vs 2.5% Benzoyl Peroxide in treating mild to moderate acne vulgaris in northern India. Materials & method: Institutional Ethics Committee evaluation verified research validity. After that, the probe began. The research layout: This Interventional, Comparative study included adolescents with acne vulgaris who visited the dermatology department at Adesh Medical College and Hospital in Shahabad Mohri, Haryana, India. Twelve to 35-year-olds participated. We need parental special pediatric informed consent for under-18 participants. Results: There were differing levels of quality of life (QoL) impairment caused by acne. Despite having acne of variable severity grades, 15.6 % of the respondents reported no QoL impairment. The CADI score revealed that the presence of acne negatively impacted respondents to differing degrees; 61.6 % experienced mild impairment in quality of life, 16.8 % moderate impairment, and 2.4 % severe impairment. The average CADI score was 4.1 ± 2.8, with males achieving a mean score of 4.4 ± 2.7 and females a mean score of 4.2 ± 2.9. Statistically speaking, this was insignificant (X2=2.87, P=0.68). The CADI score-based degree of disability by gender is presented in Table