EVALUATION OF SERIAL ABG AND OTHER BIOCHEMICAL PARAMETER AS AN EARLY PREDICTOR OF MORTALITY IN SEVERELY ILL DENGUE PATIENTS

Abstract

Background – Dengue have become major public health issue all over the world. Increasing
incidence of dengue cases over the last few decades has been lying parallel with increased
death. Mortality prediction strategies of dengue in severely ill patients will be useful in the
clinical treatment and management. The main aim of the study is to identify the correlation
between serial ABG and other biochemical parameters as a predictor of mortality in severely
ill patients with dengue.
Methods- The study of confirmed 126 severe dengue patients that were hospitalized in Index
Hospital, Indore (M.P). They were classified into two group; survivors and non-survivors.
Serial ABG and other parameter were estimated at the time of admission and after 24 hours to
MICU. Compared between survivors and non- survivors groups of clinically patients with
severe dengue to evaluated the mortality rate. The data analysis is expressed as mean and
standard deviation (S.D). Statistical comparisons were performed by student’
s t-test using the
SPSS 20.0 software. The P value <0.05 was considered to be statistically significant.
Results-Compared to survivor, the level of pH (<0.0001), PO2 (<0.0001) and bicarbonate
(<0.0001) were significantly lower in the non survivor group, while PCO2 (<0.0001) were
significantly higher in the non-survivor group after 24 hours observation in MICU. On
addition, the level of SGOT (<0.0001), SGPT (<0.0001), ALP (<0.0001) and LDH (<0.0001)
were significantly higher among the groups (non-survivor and survivor group), while other
hand, the level of urea (<0.0243), creatinine (<0.734), glucose (<0.2254) and serum albumin
(<0.718) was observed normal in the both groups.
Conclusion - ABG parameters, SGOT, SGPT, ALP and LDH is associated with severity of
dengue. These parameters may used as a prognostic and predictor marker of mortality in
severely ill patients with dengue. Further studies on it may helpful for treatment and
management of dengue.