Ketamine And Propofol Vs Fentanyl And Propofol In Total Intravenous Anaesthesia For Short Surgical Procedures: A Comparative Study In Tertiary Care Centre In South India
DOI:
https://doi.org/10.48047/Keywords:
Haemodynamic stability, TIVA, Short Surgical Procedures, Propofol, Ketamine, Fentanyl, Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure.Abstract
Background : Total intravenous anaesthesia (TIVA) is a modified form of general anaesthesia
where induction as well as maintenance of anaesthesia is done with intravenous agents alone. TIVA is administered as a combination of hypnotic and analgesic drugs without administration of any inhalation agents. The induction of intravenous anaesthetic should be sufficient to ensure that the patient loses consciousness but not to cause undesirable side effects. Primary aim of our study was to compare the Haemodynamic responses intra operatively in patients receiving Propofol-Ketamine and Propofol -Fentanyl in short surgical procedures and secondary outcome was to assess spontaneous eye opening and postoperative nausea and vomiting (PONV) in these patients.
Aims and Objectives: To compare the Ketamine and Propofol vs Fentanyl and Propofol in total
intravenous anaesthesia for short surgical procedures.
Materials & Methods: A prospective randomized study was done in 104 patients undergoing short surgical procedures of less than an hour duration for a period 18 months. patients were randomly selected into 2 groups of 52 each with ketamine and propofol or propofol and fentanyl. Haemodynamic response and recovery events were monitored
Results and Observations: There is significant difference in between groups in Heart Rate up to first 15 minutes, in systolic blood pressure and diastolic blood pressure. There is significant
difference in spontaneous eye opening, between the groups with group PF having early recovery than PK group. There is no significant difference in duration of drowsiness, emergence reactions, nausea and vomiting when both the groups were compared.
Conclusion: Increase in blood pressure with propofol-ketamine combination was due to the cardiac stimulant effect of ketamine. Propofol-Ketamine appears to be slightly better in haemodynamic stability compared to Propofol-Fentanyl. Post operative recovery is superior in Propofol-Fentanyl
