Impact of Antibiotic Use on Vaginal Microbiome and Biochemical Profiles in Women Undergoing Assisted Reproductive Technologies (ART)

Abstract

The use of antibiotics is common among women undergoing Assisted Reproductive Technologies (ART) to prevent infections and improve reproductive outcomes. However, antibiotics may disrupt the vaginal microbiome, leading to potential alterations in biochemical profiles and negatively impacting ART success. This prospective study evaluates the effects of antibiotic use on the vaginal microbiome and biochemical markers, including reproductive hormones and inflammatory markers, in women undergoing ART at Department of Obs/ Gynae, SKIMS Soura and GMC Handwara from June 2023 to June 2024. The findings suggest that antibiotic-induced changes in the vaginal microbiome may adversely influence reproductive health and ART outcomes.