Role of PRF as an adjunct in the Surgical Management of MRONJ

Abstract

Background: Medication related osteonecrosis of the jaw (MRONJ) cases are tremendously
increasing globally, thereby different treatment modalities are being developed for their
successful management.PRF is an autologous matrix scaffold, which helps to regulate
inflammation and increases healing process. Hence this study was conducted for evaluating
adjunctive role of PRF in surgical management of advanced MRONJ cases. Material and
Methods: A total of 15 patients with AAOMS stage II and III MRONJ lesions were
evaluated and surgically managed with sequestrectomy alone or sequestrectomy /currettage
with peripheral ostectomy and adjunctive application of PRF in the residual defect followed
by closure. Healing was assessed after a period of 1,3 and 6 month interval under parameters
like mucosal closure, presence of infection and radiographic disease progression upto 6
months. Results: Out of 15 patients(6 female and 9 male)included in the study,8 had AAOMS Stage III MRONJ and 7 Stage II.10 patients were treated with sequestrectomy alone and remaining 5 underwent sequestrectomy /curettage with peripheral ostectomy.11 patients reported complete mucosal healing whereas 4 experienced incomplete healing.
Conclusion: Role of PRF as an adjunct in surgically managed MRONJ cases can be considered as a favorable treatment option.