Hematological and Biochemical Profile in Acute ST Elevation Myocardial Infarction and Correlation with Early Complications

Abstract

Background.
The world’s biggest killer is ischemic heart disease, responsible for 16% of the world’s total deaths. Transient alterations in the hematological and biochemical profile are known to occur of patients admitted with acute ST elevation myocardial infarction. Some of these parameters may help to identify high risk patients with increased likelihood of developing adverse cardiac events. Identifying such high-risk patients help the treating physician to plan more aggressive treatment strategies for these patients resulting in improved clinical outcome.
Objective.
To study the baseline hematological and biochemical laboratory parameters in patients admitted with acute ST elevation myocardial infarction and correlate with their in-hospital outcome.
Methodology.
554 consecutive patients admitted to the Intensive Coronary Care Unit, Government Medical College Hospital, Kottayam with first Acute ST Elevation Myocardial Infarction during a period of one year were included in the study. Blood samples were drawn at the time of admission for estimation of hemoglobin, total and differential WBC counts, blood sugar, blood urea, serum creatinine, serum electrolytes and lipid profile. Patients were treated according to the standard protocol and any adverse cardiac events during the hospitalization period was documented and correlated with the laboratory parameters.
Results.
There was statistically significant association between the following laboratory parameters and development of in-hospital complications: lower hemoglobin values (p =0.003), higher total white blood corpuscle count (p =0.05), Background.
The world’s biggest killer is ischemic heart disease, responsible for 16% of the
world’s total deaths. Transient alterations in the hematological and biochemical
profile are known to occur of patients admitted with acute ST elevation myocardial
infarction. Some of these parameters may help to identify high risk patients with
increased likelihood of developing adverse cardiac events. Identifying such high-risk
patients help the treating physician to plan more aggressive treatment strategies for
these patients resulting in improved clinical outcome.
Objective.
To study the baseline hematological and biochemical laboratory parameters in
patients admitted with acute ST elevation myocardial infarction and correlate with
their in-hospital outcome.
Methodology.
554 consecutive patients admitted to the Intensive Coronary Care Unit,
Government Medical College Hospital, Kottayam with first Acute ST Elevation
Myocardial Infarction during a period of one year were included in the study. Blood
samples were drawn at the time of admission for estimation of hemoglobin, total and
differential WBC counts, blood sugar, blood urea, serum creatinine, serum
electrolytes and lipid profile. Patients were treated according to the standard protocol
and any adverse cardiac events during the hospitalization period was documented and
correlated with the laboratory parameters.
Results.
There was statistically significant association between the following laboratory parameters and development of in-hospital complications: lower hemoglobin values (p =0.003), higher total white blood corpuscle count (p =0.05),