A Comparative Study to Evaluate the Efficacy of Combined use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome

Abstract

Background: Psoriasis is a chronic inflammatory skin disease often linked to metabolic syndrome. This study evaluates the efficacy of combining metformin and methotrexate for treating psoriasis in these patients. Methods: The present single-blind clinical study was carried out for the duration of 1 year. This involved 50 patients with plaque psoriasis. Participants were assigned to a study group (metformin plus methotrexate) and a control group (methotrexate alone). Treatment outcomes were measured using the Psoriasis Area and Severity Index (PASI) at baseline, 1 month, 2 months, and 3 months.