EFFICACY AND SAFETY OF PRE-EMPTIVE USE OF ORAL TAPENTADOL VERSUS ORAL PREGABALIN FOR POST OPERATIVE ANALGESIA FOLLOWING CARDIAC SURGERY: A COMPARATIVE STUDY

Abstract

Background and Objective: After cardiac surgery, post operative pain is a major concern for patient as well as surgeon. Establishment of analgesia even before surgical incision is pre-emptive analgesia. Primary objective of this study is comparison of duration of analgesia in patients who were administered oral Tapentadol versus oral Pregabalin prior the surgery. Methods and Material: A prospective randomised double-blind study was conducted on 66 patients undergoing elective cardiac surgery using midline sternotomy incision. Patients were divided into two groups-Group T and Group P where patients were given oral Tapentadol 100 mg and oral Pregabalin 150 mg respectively 2 hours prior the surgery. All patients were monitored for duration of analgesia (time of first rescue analgesic after extubation from time of ingestion of the drug), VAS score, heart rate, mean arterial pressure, sedation score, intraoperative requirement of fentanyl, side effects (if any).