Assessment of Increased Risk of Incident Kidney Stone Formation in Dyslipidemia

Abstract

To assess the increased risk of Incident Kidney Stone Formation in persons with Dyslipidemia. Material and Methods: Group I comprised of Nephrolithiasis patients and group II had Healthy controls. Parameters such as height, weight, Blood pressure and BMI were recorded. About 5 mL of fasting venous blood sample was drawn for measurement of Total cholesterol (TC), Triglycerides (TG), High-density lipoprotein cholesterol (HDL-C), and Low-density lipoprotein cholesterol (LDL-C). Estimated Glomerular filtration rate (eGFR) was estimated using the 4-variable Modification of Diet in Renal Disease study equation. Results: Group I had 40 males and 30 females and group II had 35 males and 35 females. Diabetes was seen in 4 in group I and 3 in group II, Hypertension in 14 in group I and 8 in group II, Alcohol history was positive in 16 in group I and 7 in group II and Smoking history was positive in 20 in group I and 11 in group II. The difference was significant (P< 0.05). The mean TC level in group I was 172.4 mg/dl and in group II was 186.2 mg/dl. TG level was 130.5 mg/dl in group I and 116.4 mg/dl in group II, HDL- C was 44.1 mg/dl in group I and 56.2 mg/dl in group II and LDL- C was 94.4 mg/dl in group I and 104.6 mg/dl in group II. The difference was significant (P< 0.05). Hypertriglyceridemia was seen in 32 % in group I and 20% in group II, Hypercholesterolemia was seen in 28% group I and 21% in group II, low HDL-cholesterolemia was common in group I seen in 56% in group I and 18% in group II and high LDL-cholesterolemia was seen in 14% in group II and 10% in group I. The differences were significant (P< 0.05). Conclusion: Nephrolithiasis patients had high prevalence of Dyslipidemia. Hence, results showed that Dyslipidemia was associated with an increased risk of Kidney Stone Disease