Impact of Lifestyle Interventions on Non-Alcoholic Fatty Liver Disease Progression
DOI:
https://doi.org/10.48047/Keywords:
NAFLD, liver fat, lifestyle intervention, weight loss, metabolic health, disease progression, quality of life.Abstract
Background
Non-Alcoholic Fatty Liver Disease (NAFLD) is a growing global health concern, associated with obesity and metabolic syndrome. Lifestyle interventions, including dietary changes and increased physical activity, are considered effective in slowing NAFLD progression, but their impact requires further exploration. This study aimed to evaluate the effectiveness of lifestyle interventions in reducing liver fat, improving metabolic parameters, and preventing NAFLD progression over 12 months.
Methods
A total of 100 participants with NAFLD were randomized into two groups: the lifestyle intervention group (n = 50) and the control group (n = 50). The intervention group received structured dietary and physical activity guidance. Key outcomes included changes in liver fat (MRI-PDFF), weight, ALT levels, HOMA-IR, NAFLD progression, quality of life, and compliance.
Results
The lifestyle intervention group demonstrated significant reductions in liver fat (-8.2%, p < 0.001), weight (-6.3 kg, p < 0.001), ALT levels (-28%, p = 0.02), and improvements in insulin sensitivity (-18%, p = 0.04). NAFLD progression was observed in 8% of participants in the intervention group compared to 30% in the control group (p = 0.02). Quality of life significantly improved in the intervention group (+12 points, p = 0.001), and compliance was high (82%).
Conclusion
Lifestyle interventions were effective in reducing liver fat, improving metabolic health, and preventing disease progression in NAFLD patients. These findings underscore the importance of integrating lifestyle modifications in the management of NAFLD.
