CROSS-SECTIONAL ANALYSIS OF BETA-BLOCKER THERAPY IN HEART FAILURE: PATIENT OUTCOMES AND ADHERENCE

Abstract

Background: Beta-blockers are a cornerstone in the management of heart failure (HF), known to reduce mortality and improve quality of life. However, adherence to beta-blocker therapy and its impact on patient outcomes has varied, necessitating a detailed analysis.
Objectives: To assess the correlation between beta-blocker therapy adherence and patient
outcomes, including mortality, hospitalization rates, and quality of life in heart failure patients. Methods: A cross-sectional study was conducted involving 120 HF patients at a tertiary care hospital. Data on adherence to beta-blocker therapy were collected through patient self-reports and pharmacy refill records. Outcomes assessed included mortality, hospitalization, and quality of life, with statistical analysis performed to determine correlations and associations using correlation coefficients, odds ratios, and chi-square tests
Results: The study found that high adherence to beta-blocker therapy was associated with a
significant reduction in mortality (r = 0.24, P = 0.010) and hospitalization rates (OR = 1.58, P
= 0.025). Furthermore, adherence was strongly correlated with improved quality of life (r =
0.45, P = 0.0001). Demographic factors such as age and socioeconomic status significantly
influenced adherence rates, with older and more educated patients showing better adherence
Conclusions: This study underscores the importance of adherence to beta-blocker therapy in
improving clinical outcomes in HF patients. Enhanced adherence correlates with reduced
mortality and hospitalization rates and improved quality of life. These findings highlight the
need for targeted interventions to improve medication adherence among heart failure patients, particularly in demographics identified as at risk for low adherence.